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Testing for heavy metals that cause cancer


How to test for heavy metal toxicity


How do you know you have toxic heavy metals?

Determining the kind of and amount of toxic metal burden in your body is very helpful. There are several ways to help determine
this. A hair analysis will only show what has been excreted but is not helpful to show what is currently trapped in the body
tissues and unable to move out. Specific tissues can be biopsied for metals but with great expense and pain. I much prefer a pre-
and a post-challenge Urine Metals Analysis as a reasonable method to assess the body burden and kinds of heavy metals.

A Heavy Metal Urine Challenge is best performed under the supervision of a trained Naturopath or Naturopathic Medical Doctor.

Heavy metal prechallenge test

Taking a base-line, or pre-challenge urine metal test will help determine if there is any
current or ongoing exposure to heavy metals but will not give an accurate view of bound up metal burden in the tissues. Any
metals that show up in a pre-challenge Urine Metals Analysis are coming from a source of direct contact in the environment of
the individual. The source of the metal contamination must be found and eliminated immediately and steps taken to cleanse the
body of current exposure before taking a post-challenge Urine Metals Analysis.

Heavy metal post-challenge test

If the pre-challenge test comes back normal, a post-challenge test can now be made.
Once the post-challenge heavy metal urine test results are assessed they will be used to determine appropriate chelation
therapy needed to remove particular metals. The first post-challenge test also gives a baseline to track results of chelation
therapies. Taking a post-challenge test from time to time during chelation will help determine the duration of chelation needed
to bring the body back to acceptable metal levels.

A typical Urine Metal Analysis should show the body burden of metals like: Aluminum, Antimony, Arsenic, Beryllium, Bismuth,
Cadmium, Cobalt, Lead, Mercury, Nickel, Platinum, Thallium, Tin, Tungsten, Uranium. Some Urine Metals Analysis also show body
levels of essential metals like: Barium, Boron, Calcium, Chromium, Cobalt, Copper, Iron, Lithium, Magnesium, Manganese,
Molybdenum, Phosphorus, Potassium, Selenium, Sodium, Strontium, Sulfur, Vanadium, Zinc, and Zirconium.

Urine Heavy Metals Challenge tests use a provoking agent to dislodge metals from the tissues where they are trapped and escort
them to the kidneys. There are several different chemical chelators used to find various metal burdens in the body. The main
three agents used are DMPS, EDTA and DMSA. Other natural agents can be used like chlorella, cilantro, glutathione, garlic and
others. First the chelating agent is given and then the toxic metals in question are measured by the concentrations in a
subsequent six-hour urine sample. The amounts of toxic metals found in the urine sample are called the "metal spill".

The metal spill will be a combination of the toxic metal body burden, the ability to excrete via the detox pathways, and the specific
chelating agent and dose administered.

What removes toxic heavy metals from the body?

Ethylene Diamine Tetraacetic Acid (EDTA), binds avidly to lead and cadmium, less tightly to aluminum and arsenic. EDTA prefers
lead within the body but not mercury. If you are interested in specifically measuring the toxic lead burden then an EDTA
challenge is used. This is usually done by administering 3,000 mg of IV EDTA and capturing the urine for the next 6 hrs to measure
the amount of lead excreted. With this agent you may see lead, cadmium and a few other metals, but negligible amounts of
mercury regardless of the body burden of mercury because EDTA does not prefer to bind to mercury.
DMPS is a di-thiol chelator that is used to specifically find mercury in a DMPS challenge. This is usually done by administering 3
mg/kg of DMPS via IV and then collecting the urine for 6 hours. DMP S prefers and binds tightly to mercury and does not prefer
lead. Your urine sample would likely demonstrate an appreciable amount of mercury, and not much lead.
The difficulty with mercury is that it bonds tightly to mono-thiol groups in intracellular structures, such as proteins, enzymes, and
cellular DNA. Mercury damages the structure and binds so tightly to the mono-thiol that mercury can’t let go. Mercury
accumulates in the body because it is easy to get it into the body but very hard to remove. To remove Mercury it takes a two
thiol, or bi-thiol group, to bind tighter to the mercury than the one thiol group. Di-thiol chelators, DMPS and DMSA, can pull
Mercury away from the mono-thiol binding site and prevent it from re-bonding as it escorts it out of the body.
DMSA is an orally administered agent that will bind to lead, cadmium, and mercury.  We will discuss this in the later chapter on
oral chelating.
As the chelation therapy continues and health improves, it is not unusual to see a greater spill of toxic metals with subsequent
testing. It is not unusual for a Urine Heavy Metal Challenge report to look worse after a regimen of chelation. The metal burden is
not increasing, but rather the integrity of the detox pathways along with the enzyme systems.
Authored by cancer nutritionist Craig Stellpflug NDC, CNC
Dayspring Cancer Clinic Scottsdale, AZ
Copyright 2012 Craig Stellpflug© Permission is hereby granted to copy and distribute this article but only in its entirety


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